Leveraging Fermentation Heat Transfer Data to Better Understand Metabolic Activity

Biopharm International | April 1, 2008| | Copyright

ABSTRACT

Tracking the heat removal data from fermentation processes is a powerful aid in specifying scale-up characteristics such as cooling requirements. These same data can help define the metabolic activity of the cells in the fermenter. By reversing metabolic heat equations and defining the heat characteristics of the fermenter, the oxygen uptake rate can be determined from the fermenter heat removal data. This offers a simple, inexpensive method to determine the metabolic state of the fermentation. When the heat input and removal for a fermentation process have been property ...

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