The Cost of Expression of Escherichia coli lac Operon Proteins Is in the Process, Not in the Products From: Genetics | Date: March 1, 2008| Author: Dean, Antony M; Dykhuizen, Daniel E; Stoebel, Daniel M | Copyright Genetics Society of America Mar 2008. Provided by ProQuest LLC.Copyright information

ABSTRACT

Transcriptional regulatory networks allow bacteria to express proteins only when they are needed. Adaptive hypotheses explaining the evolution of regulatory networks assume that unneeded expression is costly and therefore decreases fitness, but the proximate cause of this cost is not clear. We show that the cost in fitness to Escherichia coli strains constitutively expressing the lactose operon when lactose is absent is associated with the process of making the lac gene produc...

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