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Purification of IgM Monoclonal Antibodies
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Manufacturing challenges surround the use of IgM monoclonal antibodies, but these can be overcome with current technology.
ABSTRACT
The affinity capture paradigm that dominates industrial IgG purification has proven unsuitable for IgMs because, in most cases, they are affected adversely by harsh elution conditions. The large size of IgMs is also a challenge because it limits the operating conditions and performance of traditional porousparticle-based chromatography media. This a...
Related newspaper, magazine, and journal articles from HighBeam Research
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Drug watch: Monoclonal antibodies
Formulary
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Antibody purification kit. (New Products).
Bioscience Technology
; Chromatography based purification kit uses a linked process to purify pharmaceutical antibodies. The 3-column kit facilitates the purification of polyclonal IgG (all sub-classes), monoclonal antibodies IgG (all classes), humanized antibodies, antibody fragments and antibody fusion proteins. Two of
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Monoclonal Antibodies: Principles and Practice
British Journal of Biomedical Science
; Monoclonal Antibodies: Principles and Practice J.W. Goding. London: Academic Press. 1996. ISBN 0-12-287023-9. 492 pp. L29.50. This is the third edition of Monoclonal Antibodies: Principles and Practice. While the text is directed towards a specific topic, the first six chapters deal with a more
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Impact of Lot-to-Lot Variability of Cation Exchange Chromatography Resin on Process Performance
Biopharm International
; ABSTRACT Cation exchange chromatography is commonly used as a polishing step in the purification of monoclonal antibodies. Cation exchange resins, however, typically have some lot-to-lot variability, which may result in a visually different elution profile, depending on the conditions used in the
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Monoclonal antibodies take on rheumatoid arthritis
Pharmaceutical Technology
; As targeted disease fighters, therapeutic monoclonal antibodies are revolutionizing the treatment of many illnesses, including rheumatoid arthritis.These agents work by recognizing and neutralizing antigens in the human body. Rheumatoid arthritis is a chronic inflammatory disorder that damages
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Scientists harvest antibodies from plants.(genetically engineered plants, including corn, produce monoclonal antibodies )(Brief Article)
Science News
; People may never look at a field of corn quite the same way again. Several research groups and biotech firms have genetically engineered corn and other plants to manufacture valuable human proteins called monoclonal antibodies. The scientists hope to cheaply mass-produce antibodies that can treat
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Rabbit monoclonal antibodies.(EDITOR'S Choice: MAY'S TECHNOLOGY)(Brief Article)
Bioscience Technology
; Vector Laboratories has introduced six, new rabbit monoclonal antibodies to their line of primary antibodies for immunohistochemical staining: CD3, COX-2, Cyclin D1, Ki67, Estrogen Receptor, and Progesterone Receptor. Many rabbit monoclonal antibodies bind with great affinity to their target
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Pharmaceutical Majors Build Positions in Monoclonal Antibodies
Pharmaceutical Technology
; AstraZeneca's purchase of Cambridge Antibody Technology and Merck's acquisitions of GlycoFi and Abmaxis are the latest efforts by pharmaceutical majors to build critical mass in biologies capabilities. Strong growth is projected for biologic-based drugs, and the major pharmaceutical companies are
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Biotech finally finds the bottom line: despite some setbacks, monoclonal antibodies are now poised to reap healthy profits.
U.S. News & World Report
; Say the words magic bullets, and many biotechnology investors will run the other way. Small wonder, since magic bullet is the moniker for monoclonal antibodies, which were hailed as wonder drugs in the 1980s. For all their potential, these specialized versions of the body's own immune proteins
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Monoclonal antibodies specific to cooked meats
Emerging Food R&D Report
; Widespread meat species adulteration has been found, particularly among heat-processed products. This adulteration can have serious health consequences. Preventing meat product adulteration is important in terms of maintaining consumer health and food safety. Additionally, federal, state and local
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