Topography and morphometry of intestinal mast cells in children with Hirschsprug's disease From: Folia Histochemica et Cytobiologica | Date: January 1, 2008| Author: Chyczewski, Lech; Debek, Wojciech; Dzienis-Koronkiewicz, Ewa; Hermanowicz, Adam | Copyright Folia Histochemica et Cytobiologica 2008. Provided by ProQuest LLC.Copyright information

Abstract: Mast cells (MC) are source of many biological active compounds like cytokines, arachidonic acid derivates, proteoglicanes, prostaglandins, proteases, free oxygen radials, NGF, PAF and many more. The role of MC in pathogenesis of Hirschsprung's disease (HD) is not clear. Substances produced by MC may exert an important effect on embryology, growth, differentiation and regeneration of intestinal nervous system. Additionally, MC products modulate inflammation processes thus influencing...

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