Resistance of human leukocytes to vesicular stomatitis virus infection as one of the innate antiviral immune activities; participation of cell subpopulations

Folia Histochemica et Cytobiologica | January 1, 2008| | Copyright

Abstract: Among reactions of innate immunity, resistance of human peripheral blood leukocytes (PBL) to viral infection seems important. The purpose of our study was to find, which of the subpopulations of PBL is the most responsible for the innate antiviral immunity of these cells. The innate immunity was measured by using the direct method of infection of leukocytes with vesicular stomatitis virus (VSV). The lack of VSV replication by infected leukocytes (0-1 log TCID^sub 50^) was taken as an indicator for complete immunity; a low level of VSV (2-3 log) for partial immunity; and high VSV ...

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