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Time-dependent action of DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) and its metabolite DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) on human chorionic gonadotropin and progesterone secretion
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Abstract
Explants of human placenta were used to study the effects of two isomers of DDT (1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane) [p,p'-DDT and o,p'-DDT] and their DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) metabolites [p,p'-DDE and o,p'-DDE] on the secretion of progesterone and human chorionic gonadotropin (hCG). Explants were treated with 1, 10, 100 or 1000 ng/ml of each compound for 24 h or 72 h. We found opposite effects (stimulatory after short-term and inhibitory ...
Related newspaper, magazine, and journal articles from HighBeam Research
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Effect of leptin on the regulation of placental hormone secretion in cultured human placental cells
Gynecological Endocrinology
; Abstract Placenta is an important source of leptin during pregnancy that contributes to the high plasma leptin levels in pregnant women. Leptin and its functional receptors are synthesized in trophoblast cells that, in turn, secrete gestational hormones supporting a paracrine or autocrine role for
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INTERLEUKIN-8 CAN STIMULATE PROGESTERONE SECRETION FROM A HUMAN TROPHOBLAST CELL LINE, BEWO
In Vitro Cellular & Developmental Biology
; SUMMARY Precise paracrine cross-talk between the embryo and the endometrium is essential for the establishment of a successful pregnancy. Previous studies have demonstrated that the expression of interleukin-8 (IL-8) in the endometrium is enhanced during the late-secretory phase and early
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ENDOCRINE AND PARACRINE CONTROL OF PROGESTERONE SECRETION DURING PREGNANCY
Gynecological Endocrinology
; S12 Progesterone plays a pivotal role in reproductive endocrinology, acting through endocrine and paracrine mechanisms on human endometrium and trophoblst. It is secreted from the ovary across the menstrual cycle and the first trimester of pregnancy to stimulate the decidualization of" the human
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Increased Human Chorionic Gonadotropin Due to Hypogonadism after Treatment of a Testicular Seminoma
Clinical Chemistry
; To the Editor: Alfa-fetoprotein (AFP) and serum human chorionic gonadotropin (hCG) are reliable markers of testicular cancer, and treatment of a relapse is often initiated on the basis of marker increase alone. Slightly increased hCG concentrations have occasionally been misinterpreted to indicate
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Serum levels of interleukin-6, interleukin-1[beta] and human chorionic gonadotropin in pre-eclamptic and normal pregnancy
Gynecological Endocrinology
; Abstract Studies in placentas from the first trimester and in vitro models indicate that interleukin (IL)-1β and IL-6 induce the release of human chorionic gonadotropin (hCG). During pre-eclampsia there is an increase of pro-inflammatory cytokines; however, its relationship with hCG levels
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Effects of phytoestrogens genistein and daidzein on production of human chorionic gonadotropin in term trophoblast cells in vitro
Gynecological Endocrinology
; Abstract Background. Phytoestrogens are a diverse group of non-steroidal compounds that occur naturally in many plants. Because they possess a ring system similar to estrogens they are able to bind to estrogen receptors in humans. In the present study we tested the effects of the phytoestrogens
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Acrylamide: Review of Toxicity Data and Dose-Response Analyses for Cancer and Noncancer Effects
Critical Reviews in Toxicology
; ... shown to bind directly to the microtubule-associated proteins (MAPs) MAP-I and MAP-2 (Lapadula et al., 1989). Kinesin movement in ... 1997). All of these data suggests that direct binding of ACR to MAPs coupled with ACR-induced changes in MT assembly and disassembly ...
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Progesterone: the forgotten hormone in men?
Aging Male
; ABSTRACT 'Classical' genomic progesterone receptors appear relatively late in phylogenesis, i.e. it is only in birds and mammals that they are detectable. In the different species, they mediate manifold effects regarding the differentiation of target organ functions, mainly in the reproductive
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Calcium Supplementation Increases Bone Density in Teenage Girls
Dynamic Chiropractic
; Osteoporosis is a significant health concern that now affects one in four women by age 50. Women are at higher risk than men of developing osteoporosis as a result of lower peak bone mass and rapid bone loss after menopause, which stems from a decline in estrogen and progesterone secretion. Several
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Leptin messenger ribonucleic acid (mRNA) content in the human placenta at term: Relationship to levels of leptin in cord blood and placental weight
Gynecological Endocrinology
; ... Maffei M, Braden VV, et al. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic and genetic maps of chromosome 7. Genome Res 1995;5:5-12 2. Masuzaki H, Ogawa Y, Sagawa N, et al. Nonadipose tissue production of leptin: leptin ...
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