A Method to Correct for Radioactivity in Large Vessels That Overlap the Spine in Imaging-Based Marrow Dosimetry of Lumbar Vertebrae

From: The Journal of Nuclear Medicine | Date: February 1, 2008| Author: Forero, Andres; LoBuglio, Albert; Shen, Sui; Meredith, Ruby F | Copyright information

Accurate marrow dosimetry for radionuclide therapy based on imaging methods has been challenging because of a variety of factors. One of the uncertainties in image quantification of lumbar vertebrae is correction for radioactivity in large blood vessels anterior to the vertebrae. We developed a method to correct for background radioactivity contributed from blood in large vessels and tested it in a pilot study. Methods: CT images of 26 patients receiving ^sup 111^In- or ^sup 131^I-labeled con...

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