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Impedance Spectroscopy of Bilayer Lipid Membranes Self-assembled on Agar Support - Interaction with HDL
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Summary
The electrical properties of the supported lipid bilayer membrane (s-BLM) of egg phosphatidylcholine (PC) self-assembled on agar surface were examined. To characterize the insulating properties of s-BLMs, electrochemical impedance spectroscopy (EIS) was used. The analysis of impedance spectra in terms of an equivalent circuit of agar/electrolyte and agar/s-BLM/electrolyte in the frequency range of 0.1 Hz-10 kHz was performed. The high-density lipoproteins (HDL)/s-BLM interactio...
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Distribution Spectrum of Paraoxonase Activity in HDL Fractions
Clinical Chemistry
; Background: Paraoxonase (PON1) associated with HDL can be regarded as a cardio- and vasoprotective enzyme. However, because HDL is not a homogeneous fraction, it is important to investigate in which subgroups of HDL active PON1 is located. It would also be useful to determine density profiles of
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Triglyceride-Rich HDL^sub 3^ from Patients with Familial Hypercholesterolemia Are Less Able to Inhibit Cytokine Release or to Promote Cholesterol Efflux1
The Journal of Nutrition
; ABSTRACT Familial hypercholesterolemia (FH) is associated with heterogeneity of the onset and severity of coronary heart disease (CHD). In this study, we investigated different low-grade proinflammatory markers and the atheroprotective function of the HDL^sub 3^ subfraction in FH-patients (n = 13)
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A Model Structure for the Heterodimer apoA-I^sub Milano^-apoA-II Supports Its Peculiar Susceptibility to Proteolysis
Biophysical Journal
; ABSTRACT In this study, we propose a structure for the heterodimer between apolipoprotein A-I^sub Milano^ and apolipoprotein A-II (apoA-I^sub M^-apoA-II) in a synthetic high-density lipoprotein (HDL) containing L945;-palmitoyloleoyl phosphatidylcholine. We applied bioinformatics/computational tools
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Impedance Spectroscopy of Bilayer Lipid Membranes Self-assembled on Agar Support - Interaction with HDL
Physiological Research
; Summary The electrical properties of the supported lipid bilayer membrane (s-BLM) of egg phosphatidylcholine (PC) self-assembled on agar surface were examined. To characterize the insulating properties of s-BLMs, electrochemical impedance spectroscopy (EIS) was used. The analysis of impedance
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Variability of Serial Lipoprotein-Associated Phospholipase A^sub 2^ Measurements in Post-Myocardial Infarction Patients: Results from the AIRGENE Study Center Augsburg
Clinical Chemistry
; BACKGROUND: Of the numerous emerging biomarkers for coronary heart disease (CHD), lipoprotein-associated phospholipase A^sub 2^ (Lp-PLA^sub 2 an enzyme involved in lipid metabolism and inflammatory pathways, seems to be a promising candidate. Implementation of Lp-PLA^sub 2^ measurement into
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Relations Between Particle Size of HDL and LDL Lipoproteins and Cholesterol Esterification Rate
Physiological Research
; Summary Particle size of low density (LDL) and high density (HDL) lipoproteins and cholesterol esterification rate in HDL plasma (FER^sub HDL^) are important independent predictors of coronary artery diseases (CAD). In this study we assessed the interrelations between these indicators and routinely
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Biological Variation of Coenzyme Q^sub 10^
Clinical Chemistry
; Coenzyme Q^sub 10^ (CoQ^sub 10^) is an essential cofactor in the mitochondrial electron transport chain and is found in all cell membranes. It is present in the body in both the reduced and oxidized forms, with the reduced form (CoQ^sub 10^H^sub 2^) having antioxidant properties. CoQ^sub 10^, has
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Lp-PLA^sub 2^: A New Kid on the Block
Clinical Chemistry
; Background: Atherosclerosis is a systemic disease with focal rupture of vulnerable plaque responsible for major clinical events. Several population-based studies indicate an association between lipoprotein-associated phospholipase A^sub 2^ (Lp-PLA^sub 2^) and cardiovascular events. Lp-PLA^sub 2^ is
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Lipoprotein-Associated Phospholipase A^sub 2^ Activity Is a Marker of Small, Dense LDL Particles in Human Plasma
Clinical Chemistry
; Background: Recent clinical studies showed that lipoprotein-associated phospholipase A^sub 2^ (Lp-PLA^sub 2^) is a predictor for incident atherosclerotic disease. We have previously shown that among the LDL subfractions, Lp-PLA^sub 2^ activity is preferentially associated with the atherogenic
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High Lipoprotein-Associated Phospholipase A^sub 2^ Is a Risk Factor for Recurrent Coronary Events in Postinfarction Patients
Clinical Chemistry
; Background: Recent studies demonstrate that lipoprotein-associated phospholipase A^sub 2^ (Lp-PLA^sub 2^) is a risk factor for cardiovascular disease presumably deriving from generation of proinflammatory and proatherogenic species through its hydrolytic activity on lipoprotein-associated
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