Variability of Serial Lipoprotein-Associated Phospholipase A^sub 2^ Measurements in Post-Myocardial Infarction Patients: Results from the AIRGENE Study Center Augsburg

From: Clinical Chemistry | Date: January 1, 2008| Author: | Copyright information

BACKGROUND: Of the numerous emerging biomarkers for coronary heart disease (CHD), lipoprotein-associated phospholipase A^sub 2^ (Lp-PLA^sub 2^), an enzyme involved in lipid metabolism and inflammatory pathways, seems to be a promising candidate. Implementation of Lp-PLA^sub 2^ measurement into clinical practice, however, requires data on the reliability of such measurements.

METHODS: We measured Lp-PLA^sub 2^ concentrations by ELISA in blood samples drawn from 200 post-myocardial infarction patients (39-76 years) at 6 monthly intervals between May 2003 and February 2004, for a total of 1143 ...

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