Role of the Saccharomyces cerevisiae Rad51 Paralogs in Sister Chromatid Recombination

From: Genetics | Date: January 1, 2008| Author: Fung, Cindy W; Symington, Lorraine S; Mozlin, Amy M | Copyright information

ABSTRACT

Rad51 requires a number of other proteins, including the Rad51 paralogs, for efficient recombination in vivo. Current evidence suggests that the yeast Rad51 paralogs, Rad55 and Rad57, are important in formation or stabilization of the Rad51 nucleoprotein filament. To gain further insights into the function of the Rad51 paralogs, reporters were designed to measure spontaneous or double-strand break (DSB)-induced sister or nonsister recombination. Spontaneous sister chromatid re...

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