Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells

The Journal of Nutrition | July 1, 2002| | Copyright

Deficiency in Methionine, Tryptophan, Isoleucine, or Choline Induces Apoptosis in Cultured Cells1

ABSTRACT Cells in culture die by apoptosis when deprived of the essential nutrient choline. We now report that cells (both proliferating PC 2 cells and postmitotic neurons isolated from fetal rat brains) undergo apoptosis when deprived of other individual essential nutrients (methionine, tryptophan or isoleucine). In PC 2 cells, deficiencies of each nutrient independently led to ceramide accumulation and to caspase activation, both recognized signals of several apoptotic pathways. A similar ...

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