Role of MAP kinase activation in interleukin-8 production by human BEAS-2B bronchial epithelial cells submitted to cyclic stretch From: American Journal of Respiratory Cell and Molecular Biology | Date: July 1, 2002| Author: Pugin, Jerome; Oudin, Severine | Copyright American Lung Association Jul 2002. Provided by ProQuest LLC.Copyright information

Overstretching the airways during positive pressure mechanical ventilation or attacks of acute severe asthma is associated with important biologic responses. Interleukin (IL)-8-dependent neutrophil recruitment seems to play a critical role in the process of mechanical stress-induced airway inflammation. Herein, we show that human bronchial epithelial BEAS-213 cells submitted to cyclic stretch in vitro produce IL-8, at both the mRNA and protein levels. This cellular stress "turns on" activator...

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