Hepatic iron content and the risk of Staphylococcus aureus bacteremia in liver transplant recipients

From: Progress in Transplantation | Date: December 1, 2007| Author: Akoad, Mohamed; Cacciarelli, Thomas V; Frye, Roy; Keyes, Lois; Mayher, Debra; Tickerhoof, Lisa; Wagener, Marilyn M; Wannstedt, Cheryl; Singh, Nina | Copyright information

Iron is a critical nutrient source and contributes to staphylococcal pathogenesis. We assessed the role of hepatic explant iron overload as a risk factor for Staphylococcus aureus bacteremia in liver transplant recipients. Seven of 13 cases with 5 aureus bacteremia (53.8%) had hepatic explant iron concentrations that exceeded normal limits (grade ≥ 2). Length of posttransplant intensive care unit stay (P = .013) and hepatocellular carcinoma as underlying liver disease (P = .04), but not...

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