Laminin-Binding Integrin ¿7 Is Required for Contractile Phenotype Expression by Human Airway Myocytes

From: American Journal of Respiratory Cell and Molecular Biology | Date: December 1, 2007| Author: Ens-Blackie, Karen; Gerthoffer, William T; Halayko, Andrew J; McNeill, Karol D; Rector, Edward S; Stelmack, Gerald L; Tarone, Guido; Unruh, Helmut; Tran, Thai | Copyright information

Contractile airway smooth muscle (ASM) cells retain the ability for phenotype plasticity in response to multiple stimuli, which equips them with capacity to direct modeling and remodeling during development, and in disease states such as asthma. We have shown that endogenously expressed laminin is required for maturation of human ASM cells to a contractile phenotype, as occurs during ASM thickening in asthma. In this study, we profiled the expression of laminin-binding integrins a3b1, a6b1, a...

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