Effects of methylene blue stabilizer on in vitro viability and chemotaxis of (99m)Tc-exametazime-labeled leukocytes

From: The Journal of Nuclear Medicine | Date: July 1, 2002| Author: Iverson, Barton C; Mahoney, Douglas W; Toulouse, Kyra A; Hung, Joseph C | Copyright information

This study was conducted to evaluate the effects of methylene blue/phosphate buffer stabilizer on the labeling efficiency, cell membrane integrity, chemotaxis, and in vitro stability of leukocytes labeled with ^sup 99,^Tc-exametazime. Methods: Whole blood (480 mL) was obtained from each of 3 healthy donors and divided equally into eight 60-mL aliquots. Two aliquots from each of the 3 subjects were used as a control (i.e., leukocytes were not labeled with either nonstabilized or stabilized ^su...

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