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Stress-Induced Mutagenesis in Bacteria
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ABSTRACT Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and survive these stresses, bacteria have global response systems that result in sweeping changes in gene expression and cellular metabolism. These responses are controlled by master regulators, which include: alternative sigma factors, such as RpoS and RpoH; small molecule effectors, such as ppGpp; gene repressors such as LexA; and, inorganic molecules, such as polyphosphate. The response pathways ...
Related newspaper, magazine, and journal articles from HighBeam Research
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Simulating the Temporal Modulation of Inducible DNA Damage Response in Escherichia coli
Biophysical Journal
; ABSTRACT Living organisms make great efforts to maintain their genetic information integrity. However, DNA is vulnerable to many chemical or physical agents. To rescue the cell timely and effectively, the DNA damage response system must be well controlled. Recently, single cell experiments showing
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SCIENCE; Notebook
The Washington Post
; Antibiotics can sometimes give disease-causing bacteria the ability to kill neighboring bacteria and steal their DNA -- a previously unrecognized tactic that can help the microbes resist those drugs. Drugmakers designing new medications should steer clear of compounds that can trigger this
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Controlling Mutation: Intervening in Evolution as a Therapeutic Strategy
Critical Reviews in Biochemistry and Molecular Biology
; ABSTRACT Mutation is the driving force behind many processes linked to human disease, including cancer, aging, and the evolution of drug resistance. Mutations have traditionally been considered the inevitable consequence of replicating large genomes with polymerases of finite fidelity. Observations
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Photoprotection in Human Skin-A Multifaceted SOS Response[dagger]
Photochemistry and Photobiology
; ABSTRACT Human skin has developed elaborate defense mechanisms for combating a wide variety of potentially damaging environmental factors; principal among these is UV light. Despite these defenses, short-term damage may include painful sunburn and long-term UV damage results in both accelerated
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Mutation as a Stress Response and the Regulation of Evolvability
Critical Reviews in Biochemistry and Molecular Biology
; ... mechanism of stress-inducible mutagenesis, but rather, it is a collection of mechanisms with similarities and differences. The good news is that there are several common components and broad themes evident in these mechanisms, which we shall highlight. For previous ...
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Memorial award to be presented
Dermatology Times
; Schaumburg, Ill. - From the Lila Gruber Fund award of the AAD, comes the Marion B. Sulzberger Memorial Award and Lectureship. An Academy committee selects the recipient who delivers a 30minute lecture on a subject of his or her choice during the plenary session of the annual meeting. This year,
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Sun-free tanning may be possible without risk of UV exposure
Dermatology Times
; Researchers explore the link between thymidine dinucleotide and tanning BOSTON-For many Americans, particularly those with fair hair and pale skin, that golden glow of a suntan can extract a dear price. But according to a research team at the Boston University School of Medicine, it just may be
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Making the Cut.(research on role of intein in protein splicing of bacterial RecA)
Science News
; Scientists exploit proteins that perform surgery upon themselves In the lungs of a person with tuberculosis, immune cells called macrophages do battle with the hardy bacterium responsible for the disease. Macrophages bomb the microbe, Mycobacterium tuberculosis, with oxygen-containing compounds
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Repair of (6-4) photoproducts in cultured goldfish cells at confluence or treated with H2O2
Photochemistry and Photobiology
; Nobuhiro Uchida*1,2, Hiroshi Mitani1 and Akihiro Shima1 ABSTRACT Previously we reported that fluorescent light (FL) illumination prior to UV irradiation (FL preillumination) had multiple effects on the repair of cyclobutane pyrimidine dimers (CPD) and (6-4) photoproducts ([6-4] PD) in cultured
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 "Western Mail (Cardiff, Wales)")
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Save our seas.(Features)
Western Mail (Cardiff, Wales)
; SIR - Whilst it is true that there has been a slight delay to the licensing in Cardigan Bay (Western Mail, Nov 25), your readers may be interested to know that the petition mentioned is part of a grassroots, cross-party campaign, with supporters from across Mid Wales. The petition was submitted as
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