Toward a Systems Biology of Mouse Inner Ear Organogenesis: Gene Expression Pathways, Patterns and Network Analysis From: Genetics | Date: September 1, 2007| Author: Lovett, Michael; Warchol, Mark E; Sajan, Samin A | Copyright Genetics Society of America Sep 2007. Provided by ProQuest LLC.Copyright information

ABSTRACT

We describe the most comprehensive study to date on gene expression during mouse inner ear (IE) organogenesis. Samples were microdissected from mouse embryos at E9-E15 in half-day intervals, a period that spans all of IE organogenesis. These included separate dissections of all discernible IE substructures such as the cochlea, utricle, and saccule. All samples were analyzed on high density expression microarrays under strict statistical filters. Extensive confirmatory tests we...

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