Proteinase-Activated Receptor-2 Expression in Breast Cancer and the Role of Trypsin on Growth and Metabolism of Breast Cancer Cell Line MDA MB-231

Physiological Research | January 1, 2007| | Copyright

Summary

Proteinase-activated receptor-2 (PAR-2) is a ubiquitous surface molecule participating in many biological processes. It belongs to the family of G protein-coupled receptors activated by the site-specific proteolysis of trypsin and similar proteases. Altered function of PAR-2 has been described in different malignant tumors. In the present study, we investigated the expression of PAR-2 in breast cancer surgical specimens and the role of trypsin in breast cancer cell line MDA MB-231 proliferation and metabolism. A total of 40 surgical samples of infiltrative ductal breast cancer and ...

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