Drugs Elevating Extracellular Adenosine Administered in vivo Induce Serum Colony-Stimulating Activity and Interleukin-6 in Mice

From: Physiological Research | Date: January 1, 2007| Author: Hofer, M; Pospà Streitovà Znojil, V; ¡ ¡ ­ , D; , L; sil, M; Weiterovà | Copyright information

Summary

Our previous studies have shown that the combined administration of drugs elevating extracellular adenosine, i.e. dipyridamole (DP) and adenosine monophosphate (AMP), enhances murine hematopoiesis and potentiates the action of granulocyte colony-stimulating factor (G-CSF). In this study, colony-stimulating activity (CSA) of blood serum of mice treated with DP+AMP, G-CSF or all these drugs in combination, i.e. the ability of the sera to stimulate the growth of GM-CFC colonies, w...

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