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Adaptive Mutation in Saccharomyces cerevisiae
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ABSTRACT Adaptive mutation is a generic term for processes that allow individual cells of nonproliferating cell populations to acquire advantageous mutations and thereby to overcome the strong selective pressure of proliferation-limiting environmental conditions. Prerequisites for an occurrence of adaptive mutation are that the selective conditions are nonlethal and that a restart of proliferation may be accomplished by some genetic change in principle. The importance of adaptive mutation is ...
Related newspaper, magazine, and journal articles from HighBeam Research
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Adaptive Mutation in Saccharomyces cerevisiae
Critical Reviews in Biochemistry and Molecular Biology
; ABSTRACT Adaptive mutation is a generic term for processes that allow individual cells of nonproliferating cell populations to acquire advantageous mutations and thereby to overcome the strong selective pressure of proliferation-limiting environmental conditions. Prerequisites for an occurrence of
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The Escherichia coli Histone-like Protein HU Has a Role in Stationary Phase Adaptive Mutation
Genetics
; ABSTRACT Stationary phase adaptive mutation in Escherichia coli is thought to be a mechanism by which mutation rates are increased during stressful conditions, increasing the possibility that fitness-enhancing mutations arise. Here we present data showing that the histone-like protein, HU, has a
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The Amplification Model for Adaptive Mutation: Simulations and Analysis
Genetics
; ABSTRACT It has been proposed that the lac revertants arising under selective conditions in the Cairns experiment do not arise by stress-induced mutagenesis of stationary phase cells as has been previously assumed. Instead, these revertants may arise within growing clones initiated by cells with a
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Cumulative Mutations Affecting Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae Result in Synthetic Lethality That Is Suppressed by Alterations in Sphingolipid Profiles
Genetics
; ABSTRACT UPC2 and ECM22 belong to a Zn(2)-Cys(6) family of fungal transcription factors and have been implicated in the regulation of sterol synthesis in Saccharomyces cerevisiae and Candida albicans. Previous reports suggest that double deletion of these genes in S. cerevisiae is lethal depending
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A Single Nucleotide Polymorphism in the DNA Polymerase Gamma Gene of Saccharomyces cerevisiae Laboratory Strains Is Responsible for Increased Mitochondrial DNA Mutability
Genetics
; ABSTRACT In the Saccharomyces cerevisiae strains used for genome sequencing and functional analysis, the mitochondrial DNA replicase Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of
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Telomeric Silencing of an Open Reading Frame in Saccharomyces cerevisiae
Genetics
; ... cerevisiae telomeres. A review. Biochemistry 62: 1232-1241. RILES, L., J. E. DUTCHIK, A. BAKTHA and M. V. OLSEN, 1993 Physical maps of the six smallest chromosomes of Saccharomyces cerevisiaeat a resolution of 2.6 kilobase pairs. Genetics 134: 81-150. ROTHSTEIN ...
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Translation Initiation in Saccharomyces cerevisiae Mitochondria: Functional Interactions Among Mitochondrial Ribosomal Protein Rsm28p, Initiation Factor 2, Methionyl-tRNA-Formyltransferase and Novel Protein Rmd9p
Genetics
; ABSTRACT Rsm28p is a dispensable component of the mitochondrial ribosomal small subunit in Saccharomyces cerevisiae that is not related to known proteins found in bacteria. It was identified as a dominant suppressor of certain mitochondrial mutations that reduced translation of the COX2 mRNA. To
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A Role for Sterol Levels in Oxygen Sensing in Saccharomyces cerevisiae
Genetics
; ABSTRACT Upc2p and Ecm22p are a pair of transcription factors responsible for the basal and induced expression of genes encoding enzymes of ergosterol biosynthesis in yeast (ERG genes). Upc2p plays a second role as a regulator of hypoxically expressed genes. Both sterols and heme depend upon
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Evidence That Spt10 and Spt21 of Saccharomyces cerevisiae Play Distinct Roles in Vivo and Functionally Interact With MCB-Binding Factor, SCB-Binding Factor and Snf1
Genetics
; ABSTRACT Mutations in SPT10 and SPT21 of Saccharomyces cerevisiae have been previously shown to cause two prominent mutant phenotypes: (1) defects in transcription of particular histone genes and (2) suppression of Ty and δ-insertion mutations (Spt^sup -^ phenotype). The requirement for Spt10
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Multiple regulatory mechanisms maintain zinc homeostasis in saccharomyces cerevisiae
The Journal of Nutrition
; ABSTRACT Zinc is an essential nutrient, yet it is toxic if it accumulates in excess amounts within cells; therefore the intracellular labile zinc content of cells is tightly controlled. In Saccharomyces cerevisiae, zinc homeostasis is regulated by the controlled activity of zinc uptake transporters
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