Propylene Oxide: Genotoxicity Profile of a Rodent Nasal Carcinogen

From: Critical Reviews in Toxicology | Date: July 1, 2007| Author: Sweeney, Lisa M; Albertini, Richard J | Copyright information

Propylene oxide (PO) is a DNA-reactive genotoxic agent; that is, it reacts with DNA to produce lesions in the genetic material. PO also induces tumors in rodents, although only at high concentrations and at portals of entry. This review of PO's genotoxicity profile is organized according to endpoints measured, that is, nonmutational or mutational endpoints, and as to whether the results were from in vitro or in vivo studies. In addition to results of experimental studies, PO's genotoxicity fo...

Related newspaper, magazine, and journal articles from HighBeam Research

Propylene oxide from hydrogen peroxide. (Processing).
High Performance Plastics ; ... May 2001. The company recently joined up with the US company Dow Chemical Co to further develop the process. (See also, Company news, Propylene oxide plant, this issue.) Editor's comment: PO producers are interested in the hydrogen peroxide production route ...
Propylene Oxide Enjoys Strong Demand.(Statistical Data Included)
Chemical Market Reporter ; The market faces pressure from rising feedstock costs and trouble for MTBE. SUSTAINED DEMAND for durable goods is making 1999 a strong year for propylene oxide, following an equally robust year in 1998. Demand for polyurethanes, the biggest market for P0 and their derivatives, is growing at 1.3 to
Sumitomo Plans Worldscale PO Unit Using Proprietary Technology.(propylene oxide)(Sumitomo Chemical Company Ltd.)(Brief Article)
Chemical Week ; SUMITOMO CHEMICAL SAYS IT WILL build a 200,000-m.t./year plant in Japan to produce propylene oxide (PO) using a proprietary catalytic process. It says the technology has lower costs than existing routes including the chlorohydrin PO process, and technologies that make coproducts such as styrene. It
Propylene Oxide. (Markets: Chemical Commodities).(prices, demand)(Brief Article)
Chemical Market Reporter ; PROPYLENE OXIDE Strong growth in polyurethanes has spurred demand in propylene oxide (PO), prompting at least two price increases. List prices for PO are in the range of 64 cents per pound. However, three new world-scale plants are slated to come on stream in the next 18 months, prompting fears of
PO/PG. (Markets: Chemical Commodities).(Propylene oxide and propylene glycol)(Brief Article)(Statistical Data Included)
Chemical Market Reporter ; Despite a run-up in feedstock costs such as propylene and natural gas, US propylene oxide (PO) producers have yet to attempt a price increase. The list prices for PO and propylene glycol (PG) remain at 64 cents and 68 cents, respectively. In Europe, an increase of [euro]150 per metric ton went into
HPPO plant due 2008.(BASF AG plans to contruct hydrogen peroxide and propylene oxide plant)(Brief Article)
Chemistry and Industry ; Construction of a 300 000t/year propylene oxide (PO) facility based on hydrogen peroxide (HP) will begin at BASF's (Ludwigshafen, Germany) Antwerp site in 2006 for completion in 2008. The plant will use a new HPPO technology that produces only PO and water. A 230 000t/year HP facility will be
BASF and Dow Chemical have launched a long-term venture to produce propylene oxide (PO) at the world's first commercial-scale hydrogen peroxide to PO (HPPO) plant at BASF's Antwerp, Belgium site.(propylene oxide production)(Brief article)
Chemistry and Industry ; BASF and Dow Chemical have launched a long-term venture to produce propylene oxide (PO) at the world's first commercial-scale hydrogen peroxide to PO (HPPO) plant at BASF's Antwerp, Belgium site. The plant uses a technology developed jointly by BASF and now. PO is a core ingredient for the
Sasol to commercialize propylene oxide process. (New Construction Projects).(Brief Article)
Chemical Week ; Sasol is set to build the first commercial-scale plant to produce propylene oxide (PO) based on a new process developed by Uhde and Degussa, CW has learned. The technology uses hydrogen peroxide ([H.sub.2][O.sub.2]) as a propylene oxidant (CW May 29, 2002, p. 19). The plant will have a capacity of
Dow eyes PO plant using new process. (China).(New propylene oxide and polyols complex planned)(International Pages)(Brief Article)
Chemical Week ; DOW CHEMICAL SAYS IT IS CONSIDERING building a propylene oxide (PO) and polyols complex in China. The company will decide on the project by the end of 2003, says David B. Fischer, Dow v.p./polyurethanes (PU). The planned complex should have capacities for about 250,000 m.t./year of PO and 165,000
Dow ends force majeure for PO and PG.(propylene oxide and propylene glycol)(Brief Article)
Plastics Engineering ; The Dow Chemical Co. (Midland, Mich.) has announced the end of force majeure and related volume allocations for propylene oxide (PO) and propylene glycols (PG) (effective Dec. 1, 2005). The company declared force majeure on Sept. 1, 2005, owing to disruptions to transportation logistics and raw