2-Keto-4-(Methylthio)Butyric Acid (Keto Analog of Methionine) Is a Safe and Efficacious Precursor of L-Methionine in Chicks1,2

The Journal of Nutrition | August 1, 2007| | Copyright

Abstract

Relative bioefficacy and toxicity of Met precursor compounds were investigated in young chicks. The effectiveness of DL-Met and 2-keto-4-(methylthio)butyric acid (Keto-Met) to serve as L-Met precursors was quantified using Met-deficient diets of differing composition. Efficacy was based on slope-ratio and standard-curve methodology. Using L-Met as a standard Met source added to a purified diet, DL-Met and Keto-Met were assigned relative bioefficacy values of 98.5 and 92.5%, respectively, based on weight gain. Relative bioefficacy values of 98.5 and 89.3% were assigned to DL-Met and ...

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