Zn^sup 2+^ Sensitivity of High- and Low-Voltage Activated Calcium Channels

From: Biophysical Journal | Date: August 15, 2007| Author: Feng, Zhong-Ping; Hui, Kwokyin; Lee, David W K; Sun, Hong-Shuo | Copyright information

ABSTRACT

The essential cation zinc (Zn^sup 2+^) blocks voltage-dependent calcium channels in several cell types, which exhibit different sensitivities to Zn^sup 2+^ . The specificity of the Zn^sup 2+^ effect on voltage-dependent calcium channel subtypes has not been systematically investigated. In this study, we used a transient protein expression system to determine the Zn^sup 2+^ effect on low-and high-voltage activated channels. We found that in Ba^sup 2+^, the IC^sub 50^ value of Z...

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