Involvement of Escherichia coli DNA Polymerase IV in Tolerance of Cytotoxic Alkylating DNA Lesions in Vivo From: Genetics | Date: July 1, 2007| Author: Blastier, Sophie Le; Dasgupta, Chitralekha Nag; Et al; Slade, Dea; Bjedov, Ivana | Copyright Genetics Society of America Jul 2007. Provided by ProQuest LLC.Copyright information

ABSTRACT

Escherichia coli PolIV, a DNA polymerase capable of catalyzing synthesis past replication-blocking DNA lesions, belongs to the most ubiquitous branch of Y-family DNA polymerases. The goal of this study is to identify spontaneous DNA damage that is bypassed specifically and accurately by PolIV in vivo. We increased the amount of spontaneous DNA lesions using mutants deficient for different DNA repair pathways and measured mutation frequency in PolIV-proficient and -deficient ba...

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