Radiopharmaceutical Chemistry of Targeted Radiotherapeutics, Part 3: &agr;-Particle-Induced Radiolytic Effects on the Chemical Behavior of ^sup 211^At

The Journal of Nuclear Medicine | July 1, 2007| | Copyright

Two characteristics of α-particles that enhance their potential for targeted radiotherapy are their high energy and approximately cellular range. Unfortunately, these properties also can have negative consequences, confounding the production of clinically relevant levels of radiopharmaceutical because of radiolytic effects. The purpose of this study was to evaluate the effect of radiation dose on the astatine species present before initiation of a labeling reaction and the potential role of these molecules in the efficiency of N-succinimidyl 3-2^sup 11^At-astatobenzoate (SAB) synthesis. ...

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