Drug-Herb Interaction: Effect of St John's Wort on Bioavailability and Metabolism of Procainamide in Mice

From: Archives of Pathology & Laboratory Medicine | Date: July 1, 2007| Author: | Copyright information

* Context.-St John's wort induces the activity of the cytochrome P450 enzyme system causing treatment failure because of increased metabolism of many drugs. Procainamide is metabolized by a different pathway to N-acetyl procainamide.

Objective.-To study St John's wort-procainamide interaction using a mouse (Swiss Webster) model.

Design.-One group of mice (group A, 4 mice in each group) was fed St John's wort each day for 2 weeks (last dose 1 day before administration of procainamide); another group (group B) received the same dose of St John's wort for 1 week. The third group (group C) ...

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