Pore Formation by a Bax-Derived Peptide: Effect on the Line Tension of the Membrane Probed by AFM

From: Biophysical Journal | Date: July 1, 2007| Author: Garcà ­ a-Sà ¡ ez, Ana J; Chiantia, Salvatore; Salgado, Jesà º s; Schwille, Petra | Copyright information

ABSTRACT

Bax is a critical regulator of physiological cell death that increases the permeability of the outer mitochondrial membrane and facilitates the release of the so-called apoptotic factors during apoptosis. The molecular mechanism of action is unknown, but it probably involves the formation of partially lipidic pores induced by Bax. To investigate the interaction of Bax with lipid membranes and the physical changes underlying the formation of Bax pores, we used an active peptide...

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