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Simulating the Temporal Modulation of Inducible DNA Damage Response in Escherichia coli
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ABSTRACT
Living organisms make great efforts to maintain their genetic information integrity. However, DNA is vulnerable to many chemical or physical agents. To rescue the cell timely and effectively, the DNA damage response system must be well controlled. Recently, single cell experiments showing that after DNA damage, expression of the key DNA damage response regulatory protein oscillates with time. This phenomenon is observed both in eukaryotic and bacterial cells. We establish a mo...
Related newspaper, magazine, and journal articles from HighBeam Research
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Photoprotection in Human Skin-A Multifaceted SOS Response[dagger]
Photochemistry and Photobiology
; ABSTRACT Human skin has developed elaborate defense mechanisms for combating a wide variety of potentially damaging environmental factors; principal among these is UV light. Despite these defenses, short-term damage may include painful sunburn and long-term UV damage results in both accelerated
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Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants
Genetics
; ABSTRACT DNA damage response proteins identify sites of DNA damage and signal to downstream effectors that orchestrate either apoptosis or arrest of the cell cycle and DNA repair. The C. elegans DNA damage response mutants mrt-2, hus-1, and clk-2(mn159) displayed 8- to 15-fold increases in the
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DNA damage response
The Scientist
; FOUNDATIONS "In 1986, I was trying to identify a RecA-related protein in Saccharomyces cerevisiae whose abundance increased in response to DNA damage. I expected a recombinase but when I cloned the gene, it encoded ribonucleotide reductase, which cross-reacted with the antibody I used. I was
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Prompt and delayed nonsteroidal anti-inflammatory drug-photoinduced DNA damage in peripheral blood mononuclear cells measured with the comet assay
Photochemistry and Photobiology
; Prompt and Delayed Nonsteroidal Anti-inflammatory Drug-photoinduced DNA Damage in Peripheral Blood Mononuclear Cells Measured with the Comet Assay(para) ABSTRACT Nonsteroidal anti-inflammatory drug (NSAID)-photoinduced DNA damage in human peripheral blood mononuclear cells measured using the
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DNA Damage Checkpoints Are Involved in Postreplication Repair
Genetics
; ABSTRACT Saccharomyces cerevisiae MMS2 encodes a ubiquitin-conjugating enzyme variant, belongs to the error-free branch of the RAD6 postreplication repair (PRR) pathway, and is parallel to the REV3-mediated mutagenesis branch. A mutation in genes of either the MMS2 or the REV3 branch does not
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