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Activated Protein C Resistance and Factor V Leiden: A Review
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Context.-Factor V Leiden (FVL) is the most common heritable cause of venous thrombosis. It is caused by a single nucleotide substitution resulting in an R506Q mis-sense mutation, resulting in factor V resistance to activated protein C (APC) inactivation. Carriers of FVL have an increased susceptibility to venous thrombosis, which is further increased in the presence of other genetic or environmental risk factors.
Objective.-To review the biology, clinical findings, laboratory detection...
Related newspaper, magazine, and journal articles from HighBeam Research
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Noninvasive diagnosis of deep venous thrombosis.
American Family Physician
; The diagnosis of venous thrombosis of the lower extremity is a challenge that has been met by technologic advances permitting more accurate screening. The original noninvasive tests for diagnosis of venous thrombosis included several forms of plethysmography and a hand-held Doppler. Today, the
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Bilateral ultrasonography for evaluation of suspected DVT. (deep venous thrombosis)(adapted from Radiology 1996;200:429-31)(Tips from Other Journals)
American Family Physician
; Recommendations that ultrasound screening be limited to the symptomatic extremity in patients with unilateral symptoms of deep venous thrombosis suggest that this condition be diagnosed on the basis of clinical examination alone. Naidich and associates conducted a prospective study to evaluate the
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Ultrasonography in evaluation of deep venous thrombosis. (adapted from Radiology 1995;196:379-81)(Tips from Other Journals)
American Family Physician
; Bilateral lower extremity swelling, pain and/for erythema can have many causes, including deep venous thrombosis. Although a thorough history and physical examination can exclude many causes, bilateral lower extremity ultrasonography is often requested as additional objective evidence. Clinicians
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Noninvasive diagnostic tests for deep venous thrombosis. (Tips from Other Journals)
American Family Physician
; No physical finding is pathognomonic for deep venous thrombosis, although recent studies have found that swelling of the leg is a fairly sensitive indicator of proximal deep venous thrombosis. Proximal deep venous thrombosis is believed to be more significant than thromboses confined to the calf
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Hypofibrinolysis is linked with higher venous thrombosis risk.(Cardiovascular Medicine)
Family Practice News
; Orlando -- Hypofibrinolysis is a risk factor for venous thrombosis, particularly in women, younger individuals, and those who also have Factor V Leiden, Dr. Mirjam E. Meltzer reported at the annual meeting of the American Society of Hematology. In a study of 2,420 patients with a first episode of
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