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Cadmium is Acutely Toxic for Murine Hepatocytes: Effects on Intracellular Free Ca^sup 2+^ Homeostasis
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Summary
We studied cadmium toxicity in murine hepatocytes in vitro. Cadmium effects on intracellular free Ca^sup 2+^ concentration ([Ca^sup 2+^]^sub i^) were assayed, using a laser scanning confocal microscope with a fluorescent probe, Fluo-3/AM. The results showed that administration of cadmium chloride (CdCl^sub 2^, 5, 10, 25 µM) resulted in a dose-dependent decrease of hepatocyte viability and an elevated aspartate aminotransferase (AST) activity in the culture medium (p<0.05 fo...
Related newspaper, magazine, and journal articles from HighBeam Research
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Regulation of the High-Affinity NO^sub 3^^sup -^ Uptake System by NRT1.1-Mediated NO^sub 3^^sup -^ Demand Signaling in Arabidopsis[W]
Plant Physiology
; The NRT2.1 gene of Arabidopsis thaliana encodes a major component of the root high-affinity NO^sub 3^^sup -^ transport system (HATS) that plays a crucial role in NO^sub 3^^sup -^ uptake by the plant. Although NRT2.1 was known to be induced by NO^sub 3^^sup -^ and feedback repressed by reduced
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Gene expression of the NO^sub 3^^sup -^ transporter NRT1.1 and the nitrate reductase NIA1 is repressed in Arabidopsis roots by NO^sub 2^^sup -^, the product of NO^sub 3^^sup -^ reduction
Plant Physiology
; NRT1.1 and NIA1 genes, which encode a nitrate (NO^sub 3^^sup transporter and the minor isoform of NO^sub 3^^sup -^ reductase (NR), respectively, are overexpressed in roots of NR-deficient mutants of Arabidopsis grown on nutrient solution containing NO^sub 3^^sup -^ and reduced N. The
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First Evaluation of a ^sup 99m^Tc-Tricarbonyl Complex, ^sup 99m^Tc(CO)^sub 3^(LAN), as a New Renal Radiopharmaceutical in Humans
The Journal of Nuclear Medicine
; ^sup 99m^Tc-Mercaptoacetyltriglycine (^sup 99m^Tc-MAG3), ^sup 99m^Tc-DD- and LL-ethylene-dicysteine (^sup 99m^Tc-EC), and ^sup 99m^Tc-mercaptoacetamide-ethylene-cysteine (^sup 99m^Tc-MAEC) contain N^sub 3^S or N^sub 2^S^sub 2^ ligands designed to accommodate the 4 ligating sites of the (^sup
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POLYHEDRAL MONOCARBABORANE CHEMISTRY. FUNCTIONALITY AND ISOMERISM: REACTIONS OF THE [6-Ph-nido-6-CB^sub 9^H^sub 11^]^sup -^ ANION WITH AMINOPYRIDINES NC^sub 5^H^sub 4^NH^sub 2^ TO YIELD NEUTRAL arachno AND closo TEN-VERTEX MONOCARBABORANE DERIVATIVES
Collection of Czechoslovak Chemical Communications
; Reaction of NC^sub 5^H^sub 4^-2-NH^sub 2^ with the [6-Ph-nido-6-CB^sub 9^H^sub 11sup -^ anion (1) in the presence of hydrated FeCl^sub 3^ gives [6-Ph-9-(NC^sub 5^H^sub 4^-2-NH^sub 2arachno-6-CB^sub 9^H^sub 12^] (4) and thence [1-Ph-2-(NC^sub 5^H^sub 4^-2-NH^sub 2closo-1-CB^sub 9^H^sub 8^] (5), in
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Synthesis and Biologic Evaluation of a Novel Serotonin 5-HT^sub 1A^ Receptor Radioligand, ^sup 18^F-Labeled Mefway, in Rodents and Imaging by PET in a Nonhuman Primate
The Journal of Nuclear Medicine
; Serotonin 5-HT^sub 1A^ receptors have been implicated in disorders of the central nervous system and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability of 5-HT^sub 1A^ agents currently in human use (^sup 11^C-labeled
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