Specific Defects in Different Transcription Complexes Compensate for the Requirement of the Negative Cofactor 2 Repressor in Saccharomyces cerevisiae From: Genetics | Date: May 1, 2007| Author: Estruch, Francisco; ³ -Chova, Lorena; Peirà | Copyright Genetics Society of America May 2007. Provided by ProQuest LLC.Copyright information

ABSTRACT

Negative cofactor 2 (NC2) has been described as an essential and evolutionarily conserved transcriptional repressor, although in vitro and in vivo experiments suggest that it can function as both a positive and a negative effector of transcription. NC2 operates by interacting with the core promoter and components of the basal transcription machinery, like the TATA-binding protein (TBP). In this work, we have isolated mutants that suppress the growth defect caused by the deplet...

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