Parvovirus B19 Infection in the Immunocompromised Host From: Archives of Pathology & Laboratory Medicine | Date: May 1, 2007| Author: Florea, Anca V; Ionescu, Diana N; Melhem, Mona F | Copyright College of American Pathologists May 2007. Provided by ProQuest LLC.Copyright information

Human parvovirus B19 is a single-stranded DNA virus with a predilection for infecting rapidly dividing cell lines, such as bone marrow erythroid progenitor cells. People with defective cell-mediated immunity (eg, severe combined immunodeficiency syndrome; acquired immunodeficiency syndrome; and patients receiving immunosuppressive therapy, ie, post organ transplant) can develop pure red cell aplasia, in which suppression of erythroid precursors is permanent. Identification of parvovirus inclu...

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