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Alveolar Type II Cells Isolated from Pulmonary Adenocarcinoma: A Model for JSRV Expression In Vitro
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Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring cancer in sheep, with clinical, radiologic, and histopathologic features similar to that of human pneumonic-type bronchioloalveolar carcinoma. JSRV (Jaagsiekte Sheep RetroVirus) is the etiologic agent of this contagious lung cancer in sheep. Cells involved in the tumor derive from alveolar type II cells and Clara cells, epithelial cells of the distal respiratory tract. These cells are the major site for viral expression in JSRV-inf...
Related newspaper, magazine, and journal articles from HighBeam Research
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Alveolar Type II Cells Isolated from Pulmonary Adenocarcinoma: A Model for JSRV Expression In Vitro
American Journal of Respiratory Cell and Molecular Biology
; Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring cancer in sheep, with clinical, radiologic, and histopathologic features similar to that of human pneumonic-type bronchioloalveolar carcinoma. JSRV (Jaagsiekte Sheep RetroVirus) is the etiologic agent of this contagious lung cancer in
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Intratracheal Transplantation of Alveolar Type II Cells Reverses Bleomycin-induced Lung Fibrosis
American Journal of Respiratory and Critical Care Medicine
; Rationale: Transplantation of stem cells has been proposed as a strategy for repair of lung fibrosis. Nevertheless, many studies have yielded controversial results that currently limit the potential use of these cells as an efficient treatment. Alveolar type II cells are the progenitor cells of the
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A Common Pathway for the Uptake of Surfactant Lipids by Alveolar Cells
American Journal of Respiratory Cell and Molecular Biology
; The uptake of different surfactant lipids-dipalmitoylphosphatidylcholine (DPPC), phosphatidylglycerol (PG), or phosphatidylinositol (PI)-and liposomes with a surfactant-like composition by alveolar type II cells (alveolartype II cells) and macrophages (alveolar macrophages) was studied in vitro.
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Effect of adenovector-mediated gene transfer of keratinocyte growth factor on the proliferation of Alveolar type II cells in vitro in vivo
American Journal of Respiratory Cell and Molecular Biology
; ... the monoclonal antibodies used for the KGF ELISA. They are appreciative of Lynn Cunningham for the histology and Dr. Zung Vu Tran for statistical analysis. This study was supported by grants HL-56556 and HL-29891 from the National Institutes of Health. [Reference ...
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HDL-holoparticle uptake by alveolar type II cells: Effect of vitamin E status
American Journal of Respiratory Cell and Molecular Biology
; Alveolar type II cells accumulate vitamin E preferentially from high-density lipoproteins (HDL) and express at least three receptors that are specific for HDL. The expression of these receptors increases in response to vitamin E deficiency. Beside receptors for specific lipid transfer from HDL,
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Secretion in alveolar type II cells at the interface of constitutive and regulated exocytosis
American Journal of Respiratory Cell and Molecular Biology
; Long-term, simultaneous, measurements of cytoplasmic free Call concentrations and single exocytotic fusion events in surfactant-secreting type II cells were performed. All fusion (constitutive, phorbol ester-induced, and agonist-induced) was Cal+dependent. Kinetic analysis revealed that agonist
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Rat alveolar type II cells inhibit lung fibroblast proliferation in vitro
American Journal of Respiratory Cell and Molecular Biology
; Fibroblasts stimulate alveolar type II epithelial cell differentiation and proliferation in vitro and during lung development. However, little is known about the effects of adult type II cells on fibroblasts. We investigated the effect of adult rat type II cells on proliferation of adult human lung
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Identification of Genes Differentially Expressed in Rat Alveolar Type I Cells
American Journal of Respiratory Cell and Molecular Biology
; ... M. Wolf, S. Saccone, G. Delia Valle, M. Baggiolini, and C. Schneider. 1999. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylscrine-binding protein. Genomics 57:120-129. 62. Sarkar, A., P. Yang, Y. H. Fan, Z. M ...
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Expression of CINC-2[beta] Is Related to the State of Differentiation of Alveolar Epithelial Cells
American Journal of Respiratory Cell and Molecular Biology
; Alveolar epithelial cells are among the first cells to encounter inhaled particles or organisms. These cells likely participate in the initiation and modulation of the inflammatory response by production of chemokines. However, there is little information on the extent or regulation of chemokine
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Differentiated Human Alveolar Epithelial Cells and Reversibility of their Phenotype In Vitro
American Journal of Respiratory Cell and Molecular Biology
; Cultures of differentiating fetal human type II cells have been available for many years. However, studies with differentiated adult human type II cells are limited. We used a published method for type II cell isolation and developed primary culture systems for maintenance of differentiated adult
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