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Phylogenetic Mapping of Recombination Hotspots in Human Immunodeficiency Virus via Spatially Smoothed Change-Point Processes
From:
Genetics
| Date:
April 1, 2007| Author:
Minin, Vladimir N; Dorman, Karin S; Fang, Fang; Suchard, Marc A
| Copyright Genetics Society of America Apr 2007. Provided by ProQuest LLC.Copyright information
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ABSTRACT
We present a Bayesian framework for inferring spatial preferences of recombination from multiple putative recombinant nucleotide sequences. Phylogenetic recombination detection has been an active area of research for the last 15 years. However, only recently attempts to summarize information from several instances of recombination have been made. We propose a hierarchical model that allows for simultaneous inference of recombination breakpoint locations and spatial variation i...
