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A Virtual Hair Cell, II: Evaluation of Mechanoelectric Transduction Parameters
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ABSTBACT
The virtual hair cell we have proposed utilizes a set of parameters related to its mechanoelectric transduction. In this work, we observed the effect of such channel gating parameters as the gating threshold, critical tension, resting tension, and Ca^sup 2+^ concentration. The gating threshold is the difference between the resting and channel opening tension exerted by the tip link assembly on the channel. The critical tension is the tension in the tip link assembly over which...
Related newspaper, magazine, and journal articles from HighBeam Research
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A Virtual Hair Cell, II: Evaluation of Mechanoelectric Transduction Parameters
Biophysical Journal
; ABSTBACT The virtual hair cell we have proposed utilizes a set of parameters related to its mechanoelectric transduction. In this work, we observed the effect of such channel gating parameters as the gating threshold, critical tension, resting tension, and Ca^sup 2+^ concentration. The gating
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A Virtual Hair Cell, I: Addition of Gating Spring Theory into a 3-D Bundle Mechanical Model
Biophysical Journal
; ABSTRACT We have developed a virtual hair cell that simulates hair cell mechanoelectrical transduction in the turtle utricle. This study combines a full three-dimensional hair bundle mechanical model with a gating spring theory. Previous mathematical models represent the hair bundle with a single
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Piezoelectric reciprocal relationship of the membrane motor in the cochlear outer hair cell
Biophysical Journal
; ABSTRACT It has been shown that the membrane motor in the outer hair cell is driven by the membrane potential. Here we examine whether the motility satisfies the reciprocal relationship, the characteristic of piezoelectricity, by measuring charge displacement induced by stretching the cell with
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A two-state piezoelectric model for outer hair cell motility
Biophysical Journal
; ABSTRACT Recent studies have revealed that voltage-dependent length changes of the outer hair cell are based on charge transfer across the membrane. Such a motility can be explained by an "area motor" model, which assumes two states in the motor and that conformational transitions involve transfer
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Hair cell regeneration: An exciting phenomenon . . . But will restoring hearing and balance be possible?
Journal of Rehabilitation Research and Development
; ... prevent degenerative diseases has been a high-profile topic in the news media. Stem cells are a type of cell with the capacity to self-ren ... Even this incomplete replacement, however, could be very good news for both audiologists and patients with sensorineural hearing ...
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Review of Cellular Changes in the Cochlea Due to Aminoglycoside Antibiotics
The Volta Review
; ... in the lateral wall (Ding, McFadden, Woo, & Salvi, 2002; Tran Ba Huy et al., 1983). Figures 9A through 9D show a series of ... protected by antioxidants. Free Radical Research, 30(5), 395-405. Tran Ba Huy, P., Manuel, C., Meulemans, ?., Sterkers, O., Wassef ...
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Simulation of motor-driven cochlear outer hair cell electromotility
Biophysical Journal
; ABSTRACT We propose a three-dimensional (3D) model to simulate outer hair cell electromotility. In our model, the major components of the composite cell wall are explicitly represented. We simulate the activity of the particles/motor complexes in the plasma membrane by generating active strains
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Hair cell regeneration in the avian cochlea
The Annals of Otology, Rhinology & Laryngology
; Hair cell regeneration in the avian cochlea was first identified 10 years ago in studies of hair cell loss following noise damage and aminoglycoside treatment. Since then, numerous studies from several laboratories have examined a broad spectrum of the steps involved in the regeneration process. In
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How Many States Can the Motor Molecule, Prestin, Assume in an Electric Field?
Biophysical Journal
; ABSTRACT By using an analogy between the magnetization of a paramagnetic material in an external magnetic field and the electric polarization of the lateral wall of outer hair cells in response to the transmembrane potential, we show that, based on experimental data on the charge transfer across
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Mechanisms of Aminoglycoside-Induced Hair Cell Death
The Volta Review
; Aminoglycoside antibiotics are commonly used because of their ability to treat bacterial infections, yet they also are a major cause of deafness. Aminoglycosides selectively damage the cochlea's sensory hair cells, the receptors that respond to the fluid movement in the cochlea to produce neural
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