Prevalence of hemochromatosis-related symptoms among individuals with mutations in the HFE gene

From: Mayo Clinic Proceedings | Date: June 1, 2002| Author: Beutler, Ernest; Felitti, Vincent; Gelbart, Terri; Ho, J; Waalen, Jill | Copyright information

Objective: To determine the prevalence of hemochromatosis-related symptoms in homozygotes for the HFE mutation C282Y compared with controls without HFE mutations identified through a large screening program of subjects attending a health appraisal center.

Subjects and Methods: Presence of symptoms commonly associated with clinical hemochromatosis was ascertained by self-report on a written questionnaire among C282Y homozygotes and HFE wild-type subjects of white or Hispanic ethnicity ...

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