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Melanoma Imaging with Pretargeted Bivalent Bacteriophage
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Random bacteriophage (phage) display peptide libraries have traditionally been used for the selection of clones that bind specific tissues, tumors, and antigens. However, once the targeting peptide is synthetically produced, it often displays a lower affinity than the original phage because of a lack of avidity effects and removal from the virion surface. We hypothesized that multivalent bifunctional phage displaying peptides that target novel molecular biomarkers would facilitate the in vivo imaging of cancer. This study provides proof of principle for the use of phage displaying multiple ...
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Toothpicks, Serendipity and the Emergence of the Escherichia coli DnaK (Hsp70) and GroEL (Hsp60) Chaperone Machines
; ...the Escherichia coli functions used by phage to properly execute their developmental...Because of their very short growth cycles, phage have evolved a variety of strategies to...customize host functions for their own use. Phage likely have a greater need than their hosts...
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On Kinetics of Phage Adsorption
; ...that when the receptors are absent or modified, the phage is unable to bind and the bacterium is immune to infection. Phage adsorption on host bacteria has been studied for many...case. It had been realized in early studies (5,6) that phage binding is highly efficient with the rate of adsorption...the ...
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Virus inside E. coli gives bacteria a dangerous kick
; ...coli bacteria and the virus, called a phage. Repeatedly throughout the outbreak, doctors...bacteria. But they also appear to kick the phage into overdrive -- causing it to multiply...University, studies one of the two types of phage that make toxin in E. coli O157:H7. Acheson...
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Avoiding the 'phage' attack.(Processing & Operations: Quality on the Line)
; ...as culture or starter. Bacteriaphage ( phage ) have been serious threats to starter cultures since the beginning of time. Phage may alter product quality, delay the process or cause complete failures. * What are phage? Bacteriaphage are viruses that infect...
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Retroelements Guide Adaptation
; Findings help fuel a phage-research resurgence With inquisitive minds...as a Waring blender, the work of early phage researchers such as Max Delbruck, Seymour...This and other factors relegated the phage to a mere key for unlocking the secrets...
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MICROBE OF THE MONTH: The fleece and the phage: a yarn from down under
; ...is a relationship between a particular phage and the specific bacterium or bacteria...humans and of disease-causing bacteria, a phage that is relatively common in one region...the Australian scientists to search for a phage capable of attacking D. congolensis. If...
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An antibiotic alternative?
; ...bacteria, interest has again turned to 'phage therapy', the use of bacteriophages to...complex interactions between bacterium and phage. In the early days, the multiplicity of different types of phage that could be lytic even for one host was...
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Validation of phage T7 biological dosimeter by quantitative polymerase chain reaction using short and long segments of phage T7 DNA[para]
; ABSTRACT Phage T7 can be used as a biological dosimeter...For the measurement of DNA damage in phage T7 dosimeter, a quantitative polymerase...developed using 555 and 3826 bp fragments of phage T7 DNA. Both optimized reactions are so...
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'Virus' art takes viewers on journey to heart of computer
; ...has written a software program called (phage) and launched it on a virus-like journey...Macromedia Director program used to create (phage) from Flanagan's website (www. maryflanagan...computer's role in our lives. She uses (phage) to create a "feminist map of the machine...
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Pitt program opens lab for high school students
; ...University of Pittsburgh biology department phage-hunter program. It opens a professional...study viruses called mycobacteriophages, or phage for short. It's real research in a laboratory...accepted to the program don't learn what the phage DNA looks like from a picture in a biology...
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