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^sup 18^F-Fluoroacetate: A Potential Acetate Analog for Prostate Tumor Imaging-In Vivo Evaluation of ^sup 18^F-Fluoroacetate Versus ^sup 11^C-Acetate
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PET with ^sup 11^C-acetate (^sup 11^C-ACE) has a high sensitivity for detection of prostate cancer and several other cancers that are poorly detected with ^sup 18^F-FDG. However, the short half-life (20.4 min) of ^sup 11^C limits the general availability of ^sup 11^C-ACE. ^sup 18^F-Fluoroacetate (^sup 18^F-FAC) is an analog of acetate with a longer radioactive half-life (^sup 18^F = 110 min). This study was undertaken to assess the potential usefulness of ^sup 18^F-FAC as a prostate tumor ima...
Related newspaper, magazine, and journal articles from HighBeam Research
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PET Imaging of GRP Receptor Expression in Prostate Cancer
The Journal of Nuclear Medicine
; An the United States alone, 1 in 6 men will be diagnosed with prostate cancer over the course of their lifetimes, with 31,000 dying each year from the disease. Imaging prostate cancer remains a major challenge in nuclear medicine. ^sup 18^F-FDG, the most commonly used radiotracer for the detection
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1-^sup 11^C-Acetate Kinetics of Prostate Cancer
The Journal of Nuclear Medicine
; ^sup 18^F-FDG is in widespread use in cancer imaging but has limited utility in staging and monitoring of prostate cancer. 1-^sup 11^C-Labeled acetate, a substrate for the citric acid cycle, is superior. The kinetics of prostate tumors were investigated. Methods: Ten patients with primary prostate
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(11)C-acetate PET imaging of prostate cancer
The Journal of Nuclear Medicine
; ^sup 11^C-Acetate can act as a probe of tissue metabolism through entry into catabolic or anabolic metabolic pathways as mediated by acetyl-coenzyme A. The uptake of ^sup 11^C-acetate in prostate cancer was investigated to determine whether this tracer has potential in tumor identification.
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Development of (18)F-fluoroethylcholine for cancer imaging with PET: Synthesis, biochemistry, and prostate cancer imaging
The Journal of Nuclear Medicine
; The effectiveness of ^sup 11^C-choline PET in detecting various cancers, including prostate cancer, is well established. This study was aimed at developing an ^sup 18^F-substituted choline analog, ^sup 18^F-fluoroethylcholine (FECh), as a tracer of cancer detection. Methods: No-carrier-added ^sup
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PET imaging of prostate cancer using carbon-11-choline
The Journal of Nuclear Medicine
; Prostate cancer is difficult to visualize using current techniques. Recently, ^sup 31^P magnetic resonance spectroscopy has revealed that the tumor, in general, is characterized by an increased uptake of choline into the cell to meet increased synthesis of phosphatidylcholine, an important cell
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