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SANS study on the effect of lanthanide ions and charged lipids on the morphology of phospholipid mixtures

From: Biophysical Journal  |  Date: 5/1/2002  |  Author: Glinka, Charles J; Katsaras, John; Krueger, Susan; Prosser, R Scott; Nieh, Mu-Ping

ABSTRACT The structural phase behavior of phospholipid mixtures consisting of short-chain (dihexanoyl phosphatidylcholine) and long-chain lipids (dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol), with and without lanthanide ions was investigated by small-angle neutron scattering (SANS). SANS profiles were obtained from 10 deg C to 55 deg C using lipid concentrations ranging from 0.0025 g/ml to 0.25 g/ml. The results reveal a wealth of distinct morphologies, including ...

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