Controlling the False-Positive Rate in Multilocus Genome Scans for Selection

From: Genetics | Date: February 1, 2007| Author: | Copyright information

ABSTRACT

Rapid typing of genetic variation at many regions of the genome is an efficient way to survey variability in natural populations in an effort to identify segments of the genome that have experienced recent natural selection. Following such a genome scan, individual regions may be chosen for further sequencing and a more detailed analysis of patterns of variability, often to perform a parametric test for selection and to estimate the strength of a recent selective sweep. We show here that not accounting for the ascertainment of loci in such analyses leads to false inference of natural ...

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