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Direct Measurement of Local Chromatin Fluidity Using Optical Trap Modulation Force Spectroscopy
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ABSTRACT
Chromatin assembly is condensed by histone tail-tail interactions and other nuclear proteins into a highly compact structure. Using an optical trap modulation force spectroscopy, we probe the effect of tail interactions on local chromatin fluidity. Chromatin fibers, purified from mammalian cells, are tethered between a microscope coverslip and a glass micropipette. Mechanical unzipping of tail interactions, using the micropipette, lead to the enhancement of local fluidity. Thi...
Related newspaper, magazine, and journal articles from HighBeam Research
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Laser Device Lets Biologists Immobilize and Move Cells
The Washington Post
; Imagine some kind of futuristic ray gun that could be aimed from a distance to immobilize just one person in a moving crowd. What if the marksman could then move the immobilized person to another location simply by aiming the ray gun somewhere else? Researchers at AT&T Bell Laboratories have
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Seven Cheers for Technology
The Scientist
; ... latter by helping researchers to map protein-protein interaction maps in yeast, fruit flies, nematodes, and man. Closing out the seven ... starting on page 43. Stephen Pincock has been the magazine's news editor since 2003, responsible for our daily coverage on the ...
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Forces required of kinesin during processive transport through cytoplasm
Biophysical Journal
; ABSTRACT The purpose of this paper is to deduce whether the maximum force, steplike movement, and rate of ATP consumption of kinesin, as measured in buffer, are sufficient for the task of fast transport of vesicles in cells. Our results show that moving a 200-nm vesicle in viscoelastic COS7
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 "Info-Prod Research (Middle East)")
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KSE REGISTERS NEW RECORD HIGH
Info-Prod Research (Middle East)
; According to Al-Sharq newspaper (April 15, 2008), a recently issued report by the Kuwait International Bank KIB shows that the price index of the Kuwait Stock Exchange (KSE) had registered a record high of 12558.9 points last fiscal year 2007/2008. KIB added that this increase was a result to
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 "The Economist (US)")
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Cold, quickly; Bose-Einstein condensates; A strange form of matter.(Science and Technology)(Brief Article)
The Economist (US)
; ALBERT EINSTEIN is most famous for the theory of relativity. But even if he had never thought of it, he would still have been a notable physicist. One of his other ideas, developed in the 1920s in collaboration with Satyendra Nath Bose, concerned what would happen to a collection of atoms cooled to
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Flexural Rigidity of Individual Microtubules Measured by a Buckling Force with Optical Traps
Biophysical Journal
; ABSTRACT We used direct buckling force measurements with optical traps to determine the flexural rigidity of individual microtubules bound to polystyrene beads. To optimize the accuracy of the measurement, we used two optical traps and antibody-coated beads to manipulate each microtubule. We then
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Force Unfolding Kinetics of RNA Using Optical Tweezers. I. Effects of Experimental Variables on Measured Results
Biophysical Journal
; ABSTRACT Experimental variables of optical tweezers instrumentation that affect RNA folding/unfolding kinetics were investigated. A model RNA hairpin, P5ab, was attached to two micron-sized beads through hybrid RNA/DNA handles; one bead was trapped by dual-beam lasers and the other was held by a
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A Programmable Optical Angle Clamp for Rotary Molecular Motors
Biophysical Journal
; ABSTRACT Optical tweezers are widely used for experimental investigation of linear molecular motors. The rates and force dependence of steps in the mechanochemical cycle of linear motors have been probed giving detailed insight into motor mechanisms. With similar goals in mind for rotary molecular
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Flexibility of the Neck Domain Enhances Kinesin-1 Motility under Load
Biophysical Journal
; ABSTRACT Kinesin-1 is a dimeric motor protein that moves stepwise along microtubules. A two-stranded α-helical coiled-coil formed by the neck domain links the two heads of the molecule, and forces the motor heads to alternate. By exchanging the particularly soft neck region of the conventional
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Physics and Mathematics.
Journal of the Alabama Academy of Science
; SOME EXTREMAL FAMILIES OF EDGE-REGULAR GRAPHS. Kenneth Roblee, Dept. of Mathematics and Physics, Troy State Univ., Troy, AL 36082. Tom Smotzer, Dept. of Mathematics and Statistics, Youngstown State Univ., Youngstown, OH 44555. We build on previous results concerning regular simple graphs in which
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