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Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: The pathological basis for mucin hyperproduction in mucoid otitis media
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Mucoid otitis media (MOM), one of the leading causes of acquired hearing loss in children, is characterized by mucous cell hyperplasia in the middle ear cleft associated with mucin accumulation in the middle ear cavity. The factors that stimulate mucous cell metaplasia-hyperplasia and mucin hyperproduction are poorly understood. Recent studies demonstrated that tumor necrosis factor ot (TNF-alpha), present in human middle ear effusion, stimulated mucin production in vitro and up-regulated muc...
Related newspaper, magazine, and journal articles from HighBeam Research
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TEMPERATURE-SENSITIVE SV40-IMMORTALIZED RAT MIDDLE EAR EPITHELIAL CELLS
The Annals of Otology, Rhinology & Laryngology
; The proliferation and differentiation of middle ear epithelial cells are essential in both normal and diseased middle ears. The normal situation involves physiologic growth and renewal of the epithelium, and the diseased situation involves pathological changes of the epithelium such as mucous cell
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Interleukin-10 Is an Essential Modulator of Mucoid Metaplasia in a Mouse Otitis Media Model
The Annals of Otology, Rhinology & Laryngology
; Objectives: Inflammatory cytokines are involved in the development of mucous cell metaplasia and hyperplasia (MCM) in otitis media (OM). However, which cytokines play an essential role in the MCM of OM is not clear at the moment. Methods: In this study, we hypothesized that interleukin-10 (IL-10)
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Role of tumor necrosis factor and interleukin-1 in endotoxin-induced middle ear effusions
The Annals of Otology, Rhinology & Laryngology
; In a rat model, we investigated the role of tumor necrosis factor (TNF) and interleukin-I (IL-1) in endotoxin-induced middle ear effusions (MEEs). After the eustachian tube was obstructed, the middle ear was transtympanically injected with 35 (mu)L of either 1 ) 1 mg/ mL lipopolysaccharide (LPS);
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Imaging case study of the month: Osteoma of the middle ear
The Annals of Otology, Rhinology & Laryngology
; INTRODUCTION Osteomas are rare in the temporal bone. Most commonly, they occur in the external auditory canal.l A review by Denia et al2 was notable for the absence of these lesions in the middle ear. In their report on osteoma of the temporal bone, none of 53 patients had middle ear involvement.2
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Middle Ear Adenoma
Archives of Pathology & Laboratory Medicine
; Middle ear adenoma is a benign tumor of the middle ear that can have exocrine (mucinous) and/or neuroendocrine differentiation. Early authors described a separate tumor with predominantly neuroendocrine differentiation as a middle ear carcinoid tumor, but these are now known to be the same tumor.
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