Critical appraisal of the international subarachnoid aneurysm trial (ISAT)

From: Neurology India | Date: January 1, 2004| Author: Mohr, G; Sade, B | Copyright information

Introduction

International Subarachnoid Aneurysm Trial (ISAT)[1] was designed as the first international prospective randomized trial aiming to compare the safety and efficacy of endovascular coiling with microsurgical clipping.

The first prospective randomized trial in this context was published by Koivisto et al.[2] Their single center study of 109 patients showed no difference in the clinical and neuropsychological outcomes of both treatment modalities at one year.

Imp...

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