Biological agents in rheumatoid arthritis

From: Journal of Postgraduate Medicine | Date: October 1, 2004| Author: | Copyright information

Rheumatoid arthritis (RA), the commonest inflammatory joint disease seen in clinical practice, causes significant morbidity and mortality and shortens the lifespan by 10 years.[1],[2] Aspirin, an anti-inflammatory agent, was the mainstay of RA therapy till the 1950s. The management of RA was revolutionized with the advent of corticosteroids and disease-modifying anti-rheumatic drugs (DMARDs) like methotrexate (MTX), sulphasalazine, and leflunomide as the disease course could now be modified favorably.[3] Conventional DMARDs, however, have several limitations like slow onset of action, ...

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