Therapeutic Potential of ^sup 90^Y- and ^sup 131^I-Labeled Anti-CD20 Monoclonal Antibody in Treating Non-Hodgkin's Lymphoma with Pulmonary Involvement: A Monte Carlo-Based Dosimetric Analysis

From: The Journal of Nuclear Medicine | Date: January 1, 2007| Author: Song, Hong; Du, Yong; Sgouros, George; Prideaux, Andrew; Et al | Copyright information

Pulmonary involvement is common in patients with non-Hodgkin's lymphoma (NHL). ^sup 90^Y- and ^sup 131^I-anti-CD20 antibodies (ibritumomab tiuxetan and tositumomab, respectively) have been approved for the treatment of refractory low-grade follicular NHL. In this work, we used Monte Carlo-based dosimetry to compare the potential of ^sup 90^Y and ^sup 131^I, based purely on their emission properties, in targeted therapy for NHL lung metastases of various nodule sizes and tumor burdens. Methods...

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