A Point Mutation in the Aspergillus nidulans sonB^sup Nup98^ Nuclear Pore Complex Gene Causes Conditional DNA Damage Sensitivity From: Genetics | Date: December 1, 2006| Author: De Souza, Colin P C; Hashmi, Shahr B; Horn, Kevin P; Osmani, Stephen A | Copyright Genetics Society of America Dec 2006. Provided by ProQuest LLC.Copyright information

ABSTRACT

The nuclear pore complex (NPC) is embedded in the nuclear envelope where it mediates transport between the cytoplasm and nucleus and helps to organize nuclear architecture. We previously isolated sonB1, a mutation encoding a single amino acid substitution within the Aspergillus nidulans SONBn^sup Nup98^ NPC protein (nucleoporin). Here we demonstrate that this mutation causes marked DNA damage sensitivity at 42°. Although SONBn^sup Nup98^ has roles in the G^sub 2^ transition, ...