High prevalence of spinocerebellar ataxia type 1 in an ethnic Tamil community in India

From: Neurology India | Date: July 1, 2005| Author: Arulmozhi, T; Battacharyya, N; Chattopadhyay, B; Dhanaraj, M; Rengaraj, R | Copyright information

Introduction

Spinocerebellar ataxia type 1 (SCA1) is characterized by progressive cerebellar ataxia, dysarthia and eventual bulbar dysfunction with abnormal CAG trinucleotide repeat expansion of the SCA1 gene in chromosome locus 6p23.[1] In community-based studies the prevalence rate is 1 to 2 per 100,000 populations.[1] Most of the hospital-based studies in India showed SCA2 and SCA3 to be more common.[2],[3],[4],[5],[6] In this paper, we report a population-based study of SCA1 in an ...

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