Association of Ceramides in Human Plasma with Risk Factors of Atherosclerosis

From: Lipids | Date: September 1, 2006| Author: Et al; Hidaka, Atsuko; Miyashita, Yayoi; Nakahara, Kayoko; Ichi, Ikuyo | Copyright information

ABSTRACT: Atherosclerosis is a multifactorial disorder. Recent studies indicate that the plasma level of sphingomyelin, which yields ceramide, correlates with the risk of coronary heart disease. Therefore, ceramide, a well-known lipid causing apoptosis in various cell types, may contribute to atherogenesis. We examined the relationship between ceramide concentration and risk factors of atherosclerosis in normal human plasma using electrospray tandem mass spectrometry (LC-MS/MS). Major ceramid...

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