Hypometabolism Exceeds Atrophy in Presymptomatic Early-Onset Familial Alzheimer's Disease

From: The Journal of Nuclear Medicine | Date: November 1, 2006| Author: de Leon, Mony J; Et al; Li, Yi; Sorbi, Sandro; Mosconi, Lisa | Copyright information

The aim of the present study is to compare brain atrophy with hypometabolism as preclinical markers of Alzheimer's disease (AD) by studying presymptomatic individuals from families with known early-onset autosomal dominant AD (FAD) carrying mutations in the Presenilin 1 gene. Methods: Seven asymptomatic at-risk FAD individuals (age, 35-49 y; 4 women; education ≥ 12 y) and 7 matched healthy control subjects received complete clinical, neuropsychologic, MRI, and ^sup 18^F-FDG PET examinat...

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Hypometabolism Exceeds Atrophy in Presymptomatic Early-Onset Familial Alzheimer's Disease
The Journal of Nuclear Medicine ; The aim of the present study is to compare brain atrophy with hypometabolism as preclinical markers of Alzheimer's disease (AD) by studying presymptomatic individuals from families with known early-onset autosomal dominant AD (FAD) carrying mutations in the Presenilin 1 gene. Methods: Seven
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