Interaction of technetium-99m-N-NOET with blood elements: Potential mechanism of myocardial redistribution

The Journal of Nuclear Medicine | January 1, 1997| | Copyright

Technetium-99m-N-NOET is a new ^sup 99m^Tc-labeled, neutral cardiac perfusion imaging agent which has been shown to undergo apparent redistribution in animal models and in humans. The purpose of this study was to investigate the interaction of ^sup99m^TcN-Noi-T with red blood cells (RBCs) and to determine the effects of these interactions on myocardial uptake and clearance of ^sup 99m^TcN-NOET.

Methods: After bolus administration, myocardial ^sup 99m^TcN-NOET clearance was monitored for 1 hr using a sodium iodide detector in 22 isolated, buffer-perfused rat hearts. Hearts were perfused as ...

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